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Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance

Many biological and physiological processes depend upon directed migration of cells, which is typically mediated by chemical or physical gradients or by signal relay. Here we show that cells can be guided in a single preferred direction based solely on local asymmetries in nano/microtopography on su...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sun, Xiaoyu, Driscoll, Meghan K., Guven, Can, Das, Satarupa, Parent, Carole A., Fourkas, John T., Losert, Wolfgang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611618/
https://ncbi.nlm.nih.gov/pubmed/26417076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502970112
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