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The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mutation load. This mutation load has the potential to shape patterns of adaptive evolution via genetic linkage to beneficial mutations. Here, we examine the effect of deleterious mutations on patterns o...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Koelle, Katia, Rasmussen, David A
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611170/
https://ncbi.nlm.nih.gov/pubmed/26371556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07361
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