Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

Cognitive impairment in Down syndrome (DS) has been linked to increased synaptic inhibition. The underlying mechanisms remain unknown, but memory deficits are rescued in DS mouse models by drugs targeting GABA receptors. Similarly, administration of epigallocatechin gallate (EGCG)-containing extract...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Souchet, Benoit, Guedj, Fayçal, Penke-Verdier, Zsuza, Daubigney, Fabrice, Duchon, Arnaud, Herault, Yann, Bizot, Jean-Charles, Janel, Nathalie, Créau, Nicole, Delatour, Benoit, Delabar, Jean M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611057/
https://ncbi.nlm.nih.gov/pubmed/26539088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00267
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