Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death

Chronic elevation of plasma free fatty acid (FFA) levels is commonly associated with obesity, type 2 diabetes, cardiovascular disease and some cancers. Experimental evidence indicates FFA and their metabolites contribute to disease development through lipotoxicity. Previously, we identified a specif...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Ahowesso, Constance, Black, Paul N., Saini, Nipun, Montefusco, David, Chekal, Jessica, Malosh, Chrysa, Lindsley, Craig W., Stauffer, Shaun R., DiRusso, Concetta C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610366/
https://ncbi.nlm.nih.gov/pubmed/26394026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.09.004
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