Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice

Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress t...

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Publicado en:Dis Model Mech
Autores principales: Huang, Chao-Cheng, Wang, Shuo-Yu, Lin, Li-Ling, Wang, Pei-Wen, Chen, Ting-Ya, Hsu, Wen-Ming, Lin, Tsu-Kung, Liou, Chia-Wei, Chuang, Jiin-Haur
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610240/
https://ncbi.nlm.nih.gov/pubmed/26398947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.021667
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