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mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells
Mitochondria consume O(2) to produce ATP and are critical for adaption of hypoxia, but the role of mitochondria in HIF-1α pathway is as yet unclear. In this study, mitochondrial DNA (mtDNA) enriched (SK-N-AS) and depleted (ρ(0)) cells of neuroblastoma were cultured in a hypoxic chamber to simulate a...
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| 發表在: | Int J Mol Sci |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5486043/ https://ncbi.nlm.nih.gov/pubmed/28590414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18061220 |
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