Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig

Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease by modification of single gene mutations that are responsible for the disease. They can hence be poor models for testing and development of novel drugs. Here,...

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Publicado no:Dis Model Mech
Main Authors: Hall, Vanessa J., Lindblad, Maiken M., Jakobsen, Jannik E., Gunnarsson, Anders, Schmidt, Mette, Rasmussen, Mikkel A., Volke, Daniela, Zuchner, Thole, Hyttel, Poul
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610230/
https://ncbi.nlm.nih.gov/pubmed/26398935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019489
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