Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-6/Stat3 Signaling

BACKGROUND & AIMS: Chronic inflammation promotes development and progression of colorectal cancer (CRC). We explored the distribution of the corticotropin-releasing-hormone (CRH) family of receptors and ligands in CRC and their contribution in tumor growth and oncogenic epithelial-to-mesenchymal...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Rodriguez, Jorge A., Huerta-Yepez, Sara, Law, Ivy Ka Man, Baay-Guzman, Guillermina J., Tirado-Rodriguez, Belen, Hoffman, Jill M., Iliopoulos, Dimitrios, Hommes, Daniel W., Verspaget, Hein W., Chang, Lin, Pothoulakis, Charalabos, Baritaki, Stavroula
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610032/
https://ncbi.nlm.nih.gov/pubmed/26495412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.08.001
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