Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese

Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization. We have investigated its role in intestinal metal absorption by studying a mouse model lacking intestinal DMT1 (i.e., DMT1(int/int)). DM...

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Pubblicato in:Am J Physiol Gastrointest Liver Physiol
Autori principali: Shawki, Ali, Anthony, Sarah R., Nose, Yasuhiro, Engevik, Melinda A., Niespodzany, Eric J., Barrientos, Tomasa, Öhrvik, Helena, Worrell, Roger T., Thiele, Dennis J., Mackenzie, Bryan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Nutrient Sensing, Nutrition, and Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609933/
https://ncbi.nlm.nih.gov/pubmed/26294671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00160.2015
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