BRCA1 Is Required for Maintenance of Phospho-Chk1 and G(2)/M Arrest during DNA Cross-Link Repair in DT40 Cells

The Fanconi anemia DNA repair pathway is pivotal for the efficient repair of DNA interstrand cross-links. Here, we show that FA-defective (Fancc(−)) DT40 cells arrest in G(2) phase following cross-link damage and trigger apoptosis. Strikingly, cell death was reduced in Fancc(−) cells by additional d...

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Pubblicato in:Mol Cell Biol
Autori principali: Draga, Margarethe, Madgett, Elizabeth B., Vandenberg, Cassandra J., du Plessis, David, Kaufmann, Aisling, Werler, Petra, Chakraborty, Prasun, Lowndes, Noel F., Hiom, Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609749/
https://ncbi.nlm.nih.gov/pubmed/26324327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01497-14
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