Improved pharmacokinetics and enhanced tumor growth inhibition using a nanostructured lipid carrier loaded with doxorubicin and modified with a layer-by-layer polyelectrolyte coating

A nanostructured lipid carrier (NLC) loaded with doxorubicin (DOX) has been shown to be cytotoxic against the human cancer cell lines A549 and MCF-7/Adr. In attempts to improve formulation characteristics, enhance pharmacokinetics and antitumor effects, we modified the surface of these NLC with an a...

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Bibliographic Details
Published in:Int J Pharm
Main Authors: Mussi, Samuel V., Parekh, Gaurav, Pattekari, Pravin, Levchenko, Tatyana, Lvov, Yuri, Ferreira, Lucas A.M., Torchilin, Vladimir P.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609627/
https://ncbi.nlm.nih.gov/pubmed/26325314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2015.08.079
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