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Layer-by-layer nanoencapsulation of camptothecin with improved activity

160 nm nanocapsules containing up to 60% of camptothecin in the core and 7–8 polyelectrolyte bilayers in the shell were produced by washless layer-by-layer assembly of heparin and block-copolymer of poly-L-lysine and polyethylene glycol. The outer surface of the nanocapsules was additionally modifie...

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Detalhes bibliográficos
Main Authors: Parekh, Gaurav, Pattekari, Pravin, Joshi, Chaitanya, Shutava, Tatsiana, DeCoster, Mark, Levchenko, Tatyana, Torchilin, Vladimir, Lvov, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015802/
https://ncbi.nlm.nih.gov/pubmed/24508806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2014.01.041
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