Oncolytic adenovirus targeting cyclin E overexpression repressed tumor growth in syngeneic immunocompetent mice

BACKGROUND: Clinical trials have indicated that preclinical results obtained with human tumor xenografts in mouse models may overstate the potential of adenovirus (Ad)-mediated oncolytic therapies. We have previously demonstrated that the replication of human Ads depends on cyclin E dysregulation or...

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Udgivet i:BMC Cancer
Main Authors: Cheng, Pei-Hsin, Rao, Xiao-Mei, Wechman, Stephen L., Li, Xiao-Feng, McMasters, Kelly M., Zhou, Heshan Sam
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609153/
https://ncbi.nlm.nih.gov/pubmed/26475304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1731-x
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