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DNase H Activity of Neisseria meningitidis Cas9
Type II CRISPR systems defend against invasive DNA by using Cas9 as an RNA-guided nuclease that creates double-stranded DNA breaks. Dual RNAs [CRISPR RNA (crRNA) and tracrRNA] are required for Cas9’s targeting activities observed to date. Targeting requires a protospacer adjacent motif (PAM) and crR...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4609032/ https://ncbi.nlm.nih.gov/pubmed/26474066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.020 |
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