Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.
In vitro studies have previously shown that the myelomonocytic differentiation antigen CD14 is a receptor for a complex consisting of lipopolysaccharide (LPS) and LPS-binding protein. To investigate the role of CD14 in vivo and its relationship to induction of LPS-induced endotoxin shock, transgenic...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1993
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7681594/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2380 |
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