ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification

A key component of eukaryotic lipid homeostasis is the esterification of sterols with fatty acids by sterol O-acyltransferases (SOATs). The esterification reactions are allosterically activated by their sterol substrates, the majority of which accumulate at the plasma membrane. We demonstrate that i...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Gulati, Sonia, Balderes, Dina, Kim, Christine, Guo, Zhongmin A., Wilcox, Lisa, Area-Gomez, Estela, Snider, Jamie, Wolinski, Heimo, Stagljar, Igor, Granato, Juliana T., Ruggles, Kelly V., DeGiorgis, Joseph A., Kohlwein, Sepp D., Schon, Eric A., Sturley, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608909/
https://ncbi.nlm.nih.gov/pubmed/26220175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-264796
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