Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.

Transthyretin (TTR) is thought to play a major role in vitamin A metabolism and thyroid hormone transport in mammals. To investigate the physiological role of the TTR protein in development of the embryo and in the adult, we used gene targeting techniques to generate a null mutation at the mouse ttr...

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Main Authors: Episkopou, V, Maeda, S, Nishiguchi, S, Shimada, K, Gaitanaris, G A, Gottesman, M E, Robertson, E J
Formato: Artigo
Idioma:Inglês
Publicado: 1993
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC46089/
https://ncbi.nlm.nih.gov/pubmed/8384721
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