C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways

A recent phase I clinical trial (SCIPIO) has shown that autologous c-kit+ cardiac progenitor cells (CPCs) improve cardiac function and quality of life when transplanted into patients with ischemic heart disease. Although c-kit is widely used as a marker of resident CPCs, its role in the regulation o...

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Veröffentlicht in:PLoS One
Hauptverfasser: Vajravelu, Bathri N., Hong, Kyung U., Al-Maqtari, Tareq, Cao, Pengxiao, Keith, Matthew C. L., Wysoczynski, Marcin, Zhao, John, Moore IV, Joseph B., Bolli, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608800/
https://ncbi.nlm.nih.gov/pubmed/26474484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140798
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