EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

Fetal hemoglobin (HbF, α(2)γ(2)) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin expression. EHMT1/2 catalyze mono- and dimethyl...

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Publicat a:Blood
Autors principals: Renneville, Aline, Van Galen, Peter, Canver, Matthew C., McConkey, Marie, Krill-Burger, John M., Dorfman, David M., Holson, Edward B., Bernstein, Bradley E., Orkin, Stuart H., Bauer, Daniel E., Ebert, Benjamin L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608240/
https://ncbi.nlm.nih.gov/pubmed/26320100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-649087
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