CXCR4-targeted near-infrared imaging allows detection of orthotopic and metastatic human osteosarcoma in a mouse model

CXCR4 is expressed at primary and metastatic sites of osteosarcoma. We developed a novel CXCR4-targeted near-infrared (NIR) fluorescent imaging agent (referred to as CXCR4-IR-783). The binding to representative osteosarcoma cells (F5M2 and F4 for high- and low- CXCR4 expression) was examined. CXCR4-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Guan, Guofeng, Lu, Yao, Zhu, Xiaodong, Liu, Lijuan, Chen, Jie, Ma, Qiong, Zhang, Yinglong, Wen, Yanhua, Yang, Lianjia, Liu, Tao, Wang, Wei, Ran, Henry, Qiu, Xiuchun, Ke, Shi, Zhou, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607947/
https://ncbi.nlm.nih.gov/pubmed/26472699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15244
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