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Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I

Mitochondrial complex I is a large, membrane-bound enzyme central to energy metabolism, and its dysfunction is implicated in cardiovascular and neurodegenerative diseases. An interesting feature of mammalian complex I is the so-called A/D transition, when the idle enzyme spontaneously converts from...

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Publicat a:Biochim Biophys Acta
Autors principals: Stepanova, Anna, Valls, Alba, Galkin, Alexander
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Pub. Co 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607728/
https://ncbi.nlm.nih.gov/pubmed/26009015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2015.05.012
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