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Conformational Change of Mitochondrial Complex I Increases ROS Sensitivity During Ischemia

Aims: Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusi...

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Detalhes bibliográficos
Main Authors: Gorenkova, Natalia, Robinson, Emma, Grieve, David J., Galkin, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797456/
https://ncbi.nlm.nih.gov/pubmed/23419200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4698
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