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Discovery and optimisation studies of antimalarial phenotypic hits

There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimise the ph...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Mital, Alka, Murugesan, Dinakaran, Kaiser, Marcel, Yeates, Clive, Gilbert, Ian H.
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607724/
https://ncbi.nlm.nih.gov/pubmed/26408453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.08.044
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