Circulating Th1 cell-type Tfh cells that exhibit impaired B cell help are preferentially activated during acute malaria in children

Malaria-specific antibody responses are short-lived in children, leaving them susceptible to repeated bouts of febrile malaria. The cellular and molecular mechanisms underlying this apparent immune deficiency are poorly understood. Recently, T follicular helper (Tfh) cells have been shown to play a...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Obeng-Adjei, Nyamekye, Portugal, Silvia, Tran, Tuan M., Yazew, Takele B., Skinner, Jeff, Li, Shanping, Jain, Aarti, Felgner, Philip L., Doumbo, Ogobara K., Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Crompton, Peter D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607674/
https://ncbi.nlm.nih.gov/pubmed/26440897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.004
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