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High Affinity Binding of Conformationally Constrained Synthetic Oligomers To An Antigen-Specific Antibody: Discovery of a Diagnostically Useful Synthetic Ligand For Murine Type 1 Diabetes Autoantibodies
“Antigen surrogates” are synthetic, non-natural molecules that recognize the antigen-binding sites of antibodies. These molecules are of interest as replacements for native antigens as antibody “capture agents” in ELISA-like assays of potential diagnostic utility, for example when the antibody is in...
Enregistré dans:
| Publié dans: | Bioorg Med Chem Lett |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607566/ https://ncbi.nlm.nih.gov/pubmed/26067174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.05.046 |
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