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Increased Cortical Inhibition in Autism-Linked Neuroligin-3R451C Mice Is Due in Part to Loss of Endocannabinoid Signaling
A single, maternally inherited, X-linked point mutation leading to an arginine to cysteine substitution at amino acid 451 (R451C) of Neuroligin 3 (NLGN3(R451C)) is a likely cause of autism in two brothers. Knockin mice expressing the Nlgn3(R451C) mutation in place of wild-type Nlgn3 demonstrate incr...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607423/ https://ncbi.nlm.nih.gov/pubmed/26469287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140638 |
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