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Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development

Rare variants in MDGAs (MAM domain–containing glycosylphosphatidylinositol anchors), including multiple protein-truncating deletions, are linked to autism and schizophrenia, but the function of these genes is poorly understood. Here, we show that MDGA1 and MDGA2 bound to neuroligin-2 inhibitory syna...

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Detalhes bibliográficos
Main Authors: Pettem, Katherine L., Yokomaku, Daisaku, Takahashi, Hideto, Ge, Yuan, Craig, Ann Marie
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563690/
https://ncbi.nlm.nih.gov/pubmed/23358245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206028
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