Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.

The bone-specific osteocalcin (OC) gene is transcribed only after completion of proliferation in normal diploid calvarial-derived osteoblasts during extracellular matrix mineralization. In contrast, the OC gene is expressed constitutively in both proliferating and nonproliferating ROS 17/2.8 osteosa...

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Detalhes bibliográficos
Main Authors: Bortell, R, Owen, T A, Shalhoub, V, Heinrichs, A, Aronow, M A, Rochette-Egly, C, Lutz, Y, Stein, J L, Lian, J B, Stein, G S
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46074/
https://ncbi.nlm.nih.gov/pubmed/8460137
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