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In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D-dependent transcriptional upregulation in intact cells.

The steroid hormone vitamin D is a principal mediator of skeletal homeostasis. 1,25-Dihydroxyvitamin D3 treatment of ROS 17/2.8 osteoblast-like cells results in a ligand-dependent increase in transcription of the bone-specific osteocalcin gene. This transcriptional upregulation requires the positive...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Breen, E C, van Wijnen, A J, Lian, J B, Stein, G S, Stein, J L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC45548/
https://ncbi.nlm.nih.gov/pubmed/7809144
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