Alum Adjuvant Enhances Protection against Respiratory Syncytial Virus but Exacerbates Pulmonary Inflammation by Modulating Multiple Innate and Adaptive Immune Cells

Respiratory syncytial virus (RSV) is well-known for inducing vaccine-enhanced respiratory disease after vaccination of young children with formalin-inactivated RSV (FI-RSV) in alum formulation. Here, we investigated alum adjuvant effects on protection and disease after FI-RSV immunization with or wi...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kim, Ki-Hye, Lee, Young-Tae, Hwang, Hye Suk, Kwon, Young-Man, Jung, Yu-Jin, Lee, Youri, Lee, Jong Seok, Lee, Yu-Na, Park, Soojin, Kang, Sang-Moo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607166/
https://ncbi.nlm.nih.gov/pubmed/26468884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139916
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