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The ups and downs of negative (and positive) selection of B cells

Central and peripheral tolerance checkpoints are in place to remove autoreactive B cell populations and prevent the development of autoimmunity. In this issue of the JCI, Pala and colleagues reveal that individuals with the X-linked immunodeficiency Wiskott-Aldrich syndrome (WAS) have opposite alter...

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Pubblicato in:J Clin Invest
Autori principali: Weill, Jean-Claude, Reynaud, Claude-Agnès
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607130/
https://ncbi.nlm.nih.gov/pubmed/26368305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84009
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