Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

Adoptively transferred tumor-infiltrating T lymphocytes (TILs) that mediate complete regression of metastatic melanoma have been shown to recognize mutated epitopes expressed by autologous tumors. Here, in an attempt to develop a strategy for facilitating the isolation, expansion, and study of mutat...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Cohen, Cyrille J., Gartner, Jared J., Horovitz-Fried, Miryam, Shamalov, Katerina, Trebska-McGowan, Kasia, Bliskovsky, Valery V., Parkhurst, Maria R., Ankri, Chen, Prickett, Todd. D., Crystal, Jessica S., Li, Yong F., El-Gamil, Mona, Rosenberg, Steven A., Robbins, Paul F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607110/
https://ncbi.nlm.nih.gov/pubmed/26389673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82416
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