Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production

Development and improvement of quality control tests for live attenuated vaccines are a high priority because of safety concerns. Live attenuated influenza vaccine (LAIV) viruses are 6:2 reassortants containing the hemagglutinin (HA) and neuraminidase (NA) gene segments from circulating influenza vi...

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Veröffentlicht in:J Virol Methods
Hauptverfasser: Shcherbik, Svetlana, Sergent, Sheila B., Davis, William G., Shu, Bo, Barnes, John, Kiseleva, Irina, Larionova, Natalie, Klimov, Alexander, Bousse, Tatiana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607041/
https://ncbi.nlm.nih.gov/pubmed/24056261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jviromet.2013.09.003
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