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Mutagenicity and Sequence Specificity of Acrolein-DNA Adduct
[Image: see text] Acrolein (Acr) is a major toxicant in cigarette smoke (CS); it can interact with DNA forming two major adduct isomers: α-OH-Acr-dG and γ-OH-Acr-dG. Previously, we found that the Acr-DNA binding pattern in the human p53 gene coincides with the p53 mutational pattern in CS-related lu...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4606861/ https://ncbi.nlm.nih.gov/pubmed/19146376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800369y |
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