Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4

The mechanisms underlying inflammation induced insulin resistance are poorly understood. Here, we report that the expression of PIMT, a transcriptional co-activator binding protein, was up-regulated in the soleus muscle of high sucrose diet (HSD) induced insulin resistant rats and TNF-α exposed cult...

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Pubblicato in:Sci Rep
Autori principali: Kain, Vasundhara, Kapadia, Bandish, Viswakarma, Navin, Seshadri, Sriram, Prajapati, Bhumika, Jena, Prasant K, Teja Meda, Chandana Lakshmi, Subramanian, Maitreyi, Kaimal Suraj, Sashidhara, Kumar, Sireesh T, Prakash Babu, Phanithi, Thimmapaya, Bayar, Reddy, Janardan K, Parsa, Kishore V. L., Misra, Parimal
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606566/
https://ncbi.nlm.nih.gov/pubmed/26468734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15197
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