Cognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging

Age is the main risk factor for sporadic Alzheimer’s disease. Yet, cognitive decline in aged rodents has been less well studied, possibly due to concomitant changes in sensory or locomotor function that can complicate cognitive tests. We tested mice that were 3, 11, and 23 months old in cognitive, s...

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Bibliografiske detaljer
Udgivet i:eNeuro
Main Authors: Weber, Martin, Wu, Tiffany, Hanson, Jesse E., Alam, Nazia M., Solanoy, Hilda, Ngu, Hai, Lauffer, Benjamin E., Lin, Han H., Dominguez, Sara L., Reeder, Jens, Tom, Jennifer, Steiner, Pascal, Foreman, Oded, Prusky, Glen T., Scearce-Levie, Kimberly
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
Fag:
New Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606159/
https://ncbi.nlm.nih.gov/pubmed/26473169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0047-15.2015
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