Engineering vascularized soft tissue flaps in an animal model using human adipose–derived stem cells and VEGF+PLGA/PEG microspheres on a collagen-chitosan scaffold with a flow-through vascular pedicle

Insufficient neovascularization is associated with high levels of resorption and necrosis in autologous and engineered fat grafts. We tested the hypothesis that incorporating angiogenic growth factor into a scaffold–stem cell construct and implanting this construct around a vascular pedicle improves...

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Publicado no:Biomaterials
Main Authors: Zhang, Qixu, Hubenak, Justin, Iyyanki, Tejaswi, Alred, Erik, Turza, Kristin C., Davis, Greg, Chang, Edward I., Branch-Brooks, Cynthia D., Beahm, Elisabeth K., Butler, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605897/
https://ncbi.nlm.nih.gov/pubmed/26410787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.09.024
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