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Identification of Predictive Cis-Regulatory Elements Using a Discriminative Objective Function and a Dynamic Search Space

The generation of genomic binding or accessibility data from massively parallel sequencing technologies such as ChIP-seq and DNase-seq continues to accelerate. Yet state-of-the-art computational approaches for the identification of DNA binding motifs often yield motifs of weak predictive power. Here...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Karnik, Rahul, Beer, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605740/
https://ncbi.nlm.nih.gov/pubmed/26465884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140557
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