A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ producing CD4 T-cells. By contrast, mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory T-cells that exacerbated subsequent Ct infection. We show that mucosal immu...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Stary, Georg, Olive, Andrew, Radovic-Moreno, Aleksandar F., Gondek, David, Alvarez, David, Basto, Pamela A., Perro, Mario, Vrbanac, Vladimir D., Tager, Andrew M., Shi, Jinjun, Yethon, Jeremy A., Farokhzad, Omid C., Langer, Robert, Starnbach, Michael N., von Andrian, Ulrich H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605428/
https://ncbi.nlm.nih.gov/pubmed/26089520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa8205
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