Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

Alkylated DNA-protein alkyltransferases repair alkylated DNA bases, which are among the most common DNA lesions, and are evolutionary conserved, from prokaryotes to higher eukaryotes. The human ortholog, hAGT, is involved in resistance to alkylating chemotherapy drugs. We report here on the alkylate...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Main Authors: Perugino, Giuseppe, Miggiano, Riccardo, Serpe, Mario, Vettone, Antonella, Valenti, Anna, Lahiri, Samarpita, Rossi, Franca, Rossi, Mosè, Rizzi, Menico, Ciaramella, Maria
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2015
נושאים:
Genome Integrity, Repair and Replication
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605297/
https://ncbi.nlm.nih.gov/pubmed/26227971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv774
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