Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

Alkylated DNA-protein alkyltransferases repair alkylated DNA bases, which are among the most common DNA lesions, and are evolutionary conserved, from prokaryotes to higher eukaryotes. The human ortholog, hAGT, is involved in resistance to alkylating chemotherapy drugs. We report here on the alkylate...

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Foilsithe in:Nucleic Acids Res
Main Authors: Perugino, Giuseppe, Miggiano, Riccardo, Serpe, Mario, Vettone, Antonella, Valenti, Anna, Lahiri, Samarpita, Rossi, Franca, Rossi, Mosè, Rizzi, Menico, Ciaramella, Maria
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2015
Ábhair:
Genome Integrity, Repair and Replication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605297/
https://ncbi.nlm.nih.gov/pubmed/26227971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv774
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