Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

Alkylated DNA-protein alkyltransferases repair alkylated DNA bases, which are among the most common DNA lesions, and are evolutionary conserved, from prokaryotes to higher eukaryotes. The human ortholog, hAGT, is involved in resistance to alkylating chemotherapy drugs. We report here on the alkylate...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Perugino, Giuseppe, Miggiano, Riccardo, Serpe, Mario, Vettone, Antonella, Valenti, Anna, Lahiri, Samarpita, Rossi, Franca, Rossi, Mosè, Rizzi, Menico, Ciaramella, Maria
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605297/
https://ncbi.nlm.nih.gov/pubmed/26227971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv774
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