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Bixa orellana leaf extract suppresses histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade

BACKGROUND: Histamine is established as a potent inflammatory mediator and it is known to increased endothelial permeability by promoting gap formation between endothelial cells. Previous studies have shown that aqueous extract of Bixa orellana leaves (AEBO) exhibits antihistamine activity in vivo,...

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Detalhes bibliográficos
Publicado no:BMC Complement Altern Med
Main Authors: Yong, Yoke Keong, Chiong, Hoe Siong, Somchit, Muhd Nazrul, Ahmad, Zuraini
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604723/
https://ncbi.nlm.nih.gov/pubmed/26468073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12906-015-0901-3
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