PHD1 regulates p53-mediated colorectal cancer chemoresistance

Overcoming resistance to chemotherapy is a major challenge in colorectal cancer (CRC) treatment, especially since the underlying molecular mechanisms remain unclear. We show that silencing of the prolyl hydroxylase domain protein PHD1, but not PHD2 or PHD3, prevents p53 activation upon chemotherapy...

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Pubblicato in:EMBO Mol Med
Autori principali: Deschoemaeker, Sofie, Di Conza, Giusy, Lilla, Sergio, Martín-Pérez, Rosa, Mennerich, Daniela, Boon, Lise, Hendrikx, Stefanie, Maddocks, Oliver DK, Marx, Christian, Radhakrishnan, Praveen, Prenen, Hans, Schneider, Martin, Myllyharju, Johanna, Kietzmann, Thomas, Vousden, Karen H, Zanivan, Sara, Mazzone, Massimiliano
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604688/
https://ncbi.nlm.nih.gov/pubmed/26290450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505492
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