The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A

Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves...

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Vydáno v:Sci Rep
Hlavní autoři: Vijayakrishnan, Jayaram, Henrion, Marc, Moorman, Anthony V., Fiege, Bettina, Kumar, Rajiv, Inacio da Silva Filho, Miguel, Holroyd, Amy, Koehler, Rolf, Thomsen, Hauke, Irving, Julie A., Allan, James M., Lightfoot, Tracy, Roman, Eve, Kinsey, Sally E., Sheridan, Eamonn, Thompson, Pamela D., Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Bartram, Claus R., Schrappe, Martin, Greaves, Mel, Hemminki, Kari, Harrison, Christine J., Stanulla, Martin, Houlston, Richard S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604478/
https://ncbi.nlm.nih.gov/pubmed/26463672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15065
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