The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A

Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves...

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Publicat a:Sci Rep
Autors principals: Vijayakrishnan, Jayaram, Henrion, Marc, Moorman, Anthony V., Fiege, Bettina, Kumar, Rajiv, Inacio da Silva Filho, Miguel, Holroyd, Amy, Koehler, Rolf, Thomsen, Hauke, Irving, Julie A., Allan, James M., Lightfoot, Tracy, Roman, Eve, Kinsey, Sally E., Sheridan, Eamonn, Thompson, Pamela D., Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Bartram, Claus R., Schrappe, Martin, Greaves, Mel, Hemminki, Kari, Harrison, Christine J., Stanulla, Martin, Houlston, Richard S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604478/
https://ncbi.nlm.nih.gov/pubmed/26463672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15065
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