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Functional relevance of “seed” and “non-seed” sequences in microRNA-mediated promotion of C. elegans developmental progression

The founding heterochronic microRNAs, lin-4 and let-7, together with their validated targets and well-characterized phenotypes in C. elegans, offer an opportunity to test functionality of microRNAs in a developmental context. In this study, we defined sequence requirements at the microRNA level for...

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Bibliografski detalji
Izdano u:RNA
Glavni autori: Zhang, Huibin, Artiles, Karen L., Fire, Andrew Z.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604436/
https://ncbi.nlm.nih.gov/pubmed/26385508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.053793.115
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