Efficacy of Humanized High-Dose Meropenem, Cefepime, and Levofloxacin against Enterobacteriaceae Isolates Producing Verona Integron-Encoded Metallo-β-Lactamase (VIM) in a Murine Thigh Infection Model

We aimed to describe the in vivo activity of humanized pharmacokinetic exposures of meropenem and comparators against Verona integron-encoded metallo-β-lactamase (MBL) (VIM)-producing Enterobacteriaceae in a murine model. Levofloxacin activity was predicted by its MIC, and cefepime activity displaye...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Ghazi, Islam M., Crandon, Jared L., Lesho, Emil P., McGann, Patrick, Nicolau, David P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604359/
https://ncbi.nlm.nih.gov/pubmed/26416855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00794-15
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