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Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling
Epithelial cells are major sites of malignant transformation. Atypical protein kinase C (aPKC) isoforms are overexpressed and activated in many cancer types. Using normal, highly polarized epithelial cells (MDCK and NMuMG), we report that aPKC gain of function overcomes contact inhibited growth and...
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| Publicado no: | Mol Biol Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4603929/ https://ncbi.nlm.nih.gov/pubmed/26269582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0265 |
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