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Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling
Epithelial cells are major sites of malignant transformation. Atypical protein kinase C (aPKC) isoforms are overexpressed and activated in many cancer types. Using normal, highly polarized epithelial cells (MDCK and NMuMG), we report that aPKC gain of function overcomes contact inhibited growth and...
Shranjeno v:
| izdano v: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Cell Biology
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4603929/ https://ncbi.nlm.nih.gov/pubmed/26269582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0265 |
| Oznake: |
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