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Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling

Epithelial cells are major sites of malignant transformation. Atypical protein kinase C (aPKC) isoforms are overexpressed and activated in many cancer types. Using normal, highly polarized epithelial cells (MDCK and NMuMG), we report that aPKC gain of function overcomes contact inhibited growth and...

詳細記述

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書誌詳細
出版年:Mol Biol Cell
主要な著者: Archibald, Andrew, Al-Masri, Maia, Liew-Spilger, Alyson, McCaffrey, Luke
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Cell Biology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603929/
https://ncbi.nlm.nih.gov/pubmed/26269582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-05-0265
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